ODCs

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1 OMIM reference -
2 associated genes
14 signs/symptoms

COMMON GENES: 2
COMMON SIGNS: 5

1 OMIM reference -
2 associated genes
11 signs/symptoms

Hypoplastic tibiae - postaxial polydactyly

Triphalangeal thumb - polysyndactyly syndrome

LMBR1	(UniProt - OMIM)		LMBR1	(UniProt - OMIM)
SHH	(UniProt - OMIM)		SHH	(UniProt - OMIM)

Citations in the biomedical literature:

Hypoplastic tibiae - postaxial polydactyly		Triphalangeal thumb - polysyndactyly syndrome
	Synonym(s): - Werner mesomelic syndrome		Synonym(s): - TPT-PS syndrome

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C536563


COMMON SIGNS	- Autosomal dominant inheritance - Fingerlike / triphalangeal thumb - Postaxial polydactyly (hand) - Preaxial polydactyly (hand) - Syndactyly of fingers / interdigital palm

Hypoplastic tibiae - postaxial polydactyly		Triphalangeal thumb - polysyndactyly syndrome
	Very frequent - Bowed diaphysis / diaphyses / long bones - Clinodactyly of fifth finger - Fibula anomaly (excluding short) / absence / agenesis / hypoplasia / fibular ray anomaly - Tibia anomaly (excluding short) / absence / agenesis / hypoplasia / tibial ray anomaly Occasional - Complete claw hand / camptodactyly of all fingers - Restricted joint mobility / joint stiffness / ankylosis - Short columella / depressed nasal tip - Short stature / dwarfism / nanism - Thumb hypoplasia / aplasia / absence		Frequent - Metacarpal anomalies / Archibald's sign - Syndactyly of toes - Thumb duplication / distal bifid thumb phalangeal bone Occasional - Broad / bifid thumb - Postaxial polydactyly of toes / fifth supernumerary toe - Preaxial polydactyly of toes / big toe duplication